Monday, 23 July

8.30 am – 10.15 am Axons of motoneurons (Chair: Simon Gandevia)

Simon GandeviaWelcome

Hugh Bostock – In vivo assessment of motor axon and muscle membrane properties

François Couraud – Properties of the axon initial segment

Janet Taylor – Changes in the recurrent discharge of human motoneurons

Claire Meehan – Compensation in mouse model of amyotrophic lateral sclerosis (ALS)

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10.45 am – 12.15 pm Motoneuron properties (Chair: Bob Fyffe)

Ken Rose – Distribution of synapses, channels, and transporters: the view from the motoneuron dendritic tree

Adam Deardorff – Expression of Ca2+-activated potassium (SK) channels in normal and axotomized α-motoneurons

Rodolfo Delgado-Lezama – Extrasynaptic GABAA receptors regulate excitability of motoneurons in the mature spinal cord

Peter Noakes – Independent regulation of motoneuron survival during development by central synaptic activity

Ian Johnson – Rescue of motoneurons: an ageing problem
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1.30 pm – 3.15 pm Voluntary control of motoneurons (Chair: Gabrielle Todd)

David Burke – Measuring the excitability of the motoneurone pool

Dario Farina – Origin of coherence peaks in the spike trains of populations of motor units

Minoru Shinohara – Corticomuscular coherence with and without EMG rectification during single and multi tasks in young and elderly adults

Tjeerd Boonstra – Mechanisms and dynamics of oscillatory input to motoneurons

Maria Piotrkiewicz – Impact of synaptic noise on the stimuluscorrelated motoneuron firing (computer simulation study)

CJ Heckman – Reverse engineering of motor unit firing patterns to estimate the synaptic structure of motor commands
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3.45 pm – 4.45 pm Historical session. Motoneurons: on the shoulders of giants (Chair: David Burke)

Doug Stuart – Pioneers of active CNS inhibition I: Ivan Sechenov, Charles Sherrington, and John Eccles

Robert Callister – Pioneers of active CNS inhibition II: David Curtis and the search for inhibitory neurotransmitters in the spinal cord

Paul Foley – The MND/ALS concept: Alfred Campbell’s pre-WWII contributions
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Tuesday, 24 July

8.30 am – 10.15 am Rythmic control of motoneurons (Chair: Claire Meehan)

Reggie Edgerton - Sources of control of the rhythmicity of stepping

Hans Hultborn - Motoneuron properties during fictive rhythmic movements in the decerebrate cat

Aidas Alaburda - Temporal integration during initiation of scratching

Gareth Miles - Spinally-derived modulation of motoneuron output

Katrina Maluf - Age-related changes in chest wall movement and respiratory modulation of motor unit behavior in the trapezius muscle

Jack Feldman - Rhythmic drive to motoneurons
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10.45 am – 12.30 pm Motoneuron disease (Chair: Zev Rymer)

Matthew Kiernan - Motoneurons: what have we learned from ALS?

Jacques Durand - Common early alterations in lumbar motoneurons of SOD1G93A and SOD1G85R juvenile mice

Daniel Zytniki - Degeneration of motoneurons in SOD1 mice: the size hypothesis

Sherif ElBasiouny - G85R and G93A-h models of ALS: similar size abnormality but opposite alterations in membrane biophysical properties

Matthew Fogarty - Motoneuron hyperexcitability in SODG93Ah mice is associated with increased dendritic arborisation and glutamatergic synapses

Michael Swash - Motor unit recruitment in ALS and other UMN lesions
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3.00 am – 5.00 pm Motoneuron adaptation (Chair: CJ Heckman)

Rob Brownstone - Spike frequency adaptation in motoneurons: is it an artefact?

Piotr Krutki - Effects of the muscle overload on the medial gastrocnemius motor units and motoneurons

Jayne Carberry - Respiratory muscle adaptation following chronic hypoxia during postnatal development

Curtis Manning - Fatigue of motoneurons

Chris McNeil - Motoneuron excitability following a locomotor vs. an isometric fatigue task
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Wednesday, 25 July

9.00 am – 10.30 am Motoneuron behaviour in people (Chair: Inge Zijdewind)

Andy Fuglevand - Motor unit synchrony: cortical imprint or not

Jacques Duchateau - Initial conditions influence the discharge of single motor units during fast contractions

Martin Héroux - Triceps surae muscle motor unit behaviour during human standing balance

Kemal Türker - Frequency analysis of the reflex responses of human masseter motor units

Paul Hodges - Non-uniform effects of nociceptive input to motoneurons during experimental pain
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11.00 am – 12.30 pm Motoneurons and persistent inward currents, etc (Chair: Marc Binder)

Jørn Hounsgaard - Motoneurons, what makes them tick?

Randy Powers - Contributions of sodium and potassium currents to synaptic integration in motoneurons

Bob Lee - Interaction between Na PICs and motoneuron firing properties

Jessica D’Amico - Role of constitutively-active 5HT2 receptors in involuntary muscle spasms after spinal cord injury in humans

Dave Collins - Driving motoneurons with repetitive reflexive inputs after a spinal cord injury
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3.30 pm – 5.00 pm Motoneurons after spinal cord injury (Chair: Jane Butler)

Gary Sieck - Recovery of phrenic motoneuron activity after cervical spinal cord injury

George Hornby - Sustained amplification of volitional motor function in spinal cord injury: role of PICs in rehabilitation

Christine Thomas - Reduced spinal inhibition increases stretch- induced activation of muscles paralyzed by spinal cord injury

Chris Thompson - Supramaximal volitional torque in humans with spinal cord injury: reflexive and perceptual consequences

Krzysztof Kowalski - Respiratory motoneuron activation during high frequency spinal cord stimulation (HF-SCS)
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